The nerve cells in the brain are equipped with a signal transmission system network (neural circuit, neural network) through synaptic connections with each other. The human brain has 86 billion nerve cells and a synaptic connection network of 100-120 trillion. The regular and balanced establishment and operation of the connections that form the synaptic network between these nerve cells, meaning the maintenance of signal transmissions at appropriate electrical voltage and frequency (rate), is directly related to the balance/imbalance in behaviors. In the signal transmission system, there is a balance of excitation/inhibition (E/I). With the continuously regenerated nerve cells (neurogenesis) and synapses (synaptogenesis), and the millions of new connections that will form in the signal transmission systems, the excitation/inhibition (E/I) balance in each of them should be structured and maintained in a healthy and proper manner (suitable for the entire network system within the brain). The disruption of this balance, which often involves excessive excitation (hyper-excitation), high voltage, and irregular frequency in the brains of children with autism, directly negatively affects the functions of the relevant centers in the brain and results in the emergence of many differences, including the behavioral problems observed in autism.









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