In scientific studies, the presence of three significant pathological changes in the brains of individuals of different age groups who died with an autism diagnosis was identified through brain autopsy studies conducted with special permissions.

1. Inflammation affecting nerve cells within the brain

2. An increase in the number and disproportionate changes in the diversity of important cells within the brain (microglia cells and astrocytes; the production and plasticity of nerve cells and synapses, pruning of synapses, covering nerve cells with myelin sheaths; myelin production, maintaining the balance of excitation and inhibition of synapses, and the integrity of the blood-brain barrier) have been identified as responsible for disorders related to the number, structure, and function of nerve cells, including synaptic pruning disorders and imbalances in excitation and inhibition.

3. Disorders in signal transmission systems between nerve cells. In the brain, information and commands are transmitted in the form of signal transmission. Signal transmission disorders can be related to the capabilities of the relevant housing and can lead to problems.