In studies conducted on children diagnosed with autism, the presence of three different problems in the immune system has been reported. These mainly include: 1. Dysregulation of the immune system; problems in the regulation of the immune response due to imbalances in the quantities of immune cells (CD4+, CD25+, IL-10, TGF-ß) responsible for the initiation (activation) and termination (inhibition) of the immune response. 2. Increase in autoimmunity and autoantibodies; The most important feature of the immune system is its ability to distinguish between what is self and what is non-self, meaning foreign, and to respond only to foreign molecules and cells by recognizing, analyzing, presenting, and ultimately providing destructive, selective, and discriminative responses (self, non-self distinction). The loss of distinguishing characteristics of immune system cells, resulting in the body responding destructively to its own cells, is called autoimmunity, and the diseases that occur due to these mechanisms are referred to as autoimmune diseases. The destructive cells that mediate autoimmune responses are also called autoantibodies. In autism, an increase in autoimmune response tendencies and the production of mediating autoantibodies has been identified. 3. Increase in inflammation activation; Although inflammation is actually a mechanism of resistance and defense for the body, the stimulation of inflammation in the brain by signaling molecules (pro-inflammatory cytokines; IL1ß, TNFα, IL-6) that initiate inflammation leads to an uncontrolled and excessive inflammatory response, causing pathological changes in nerve cells and dysfunctions in signaling transmission systems in the brain. In autism, an increase in inflammation activation in the brain has been reported.