The low levels of both zinc and selenium together can be explained by the activation of inflammation and oxidative stress pathways. One reason for this situation could be an increase in intestinal permeability. Increased permeability of the Gut-Brain Barrier, which can be determined through laboratory measurement: The amount of Zonulin should be measured from stool, fecal samples. The normal value should be <42 µU/g. High values indicate an increase in intestinal permeability according to the degree. In fact, one reason for low zinc levels is high selenium levels. Because high selenium prevents the absorption of zinc. In selenium deficiency, zinc levels may also be elevated. Selenium prevents the absorption of zinc. While there is no intestinal permeability, the low levels of both together; observed in autism; can be explained by the activation of inflammation and oxidative stress pathways. Because oxidative stress is also activated after inflammation activation.