The medical holistic approach in autism can be explained under two main headings. 1. Examination of pre-brain systems. 2. Pathological changes that can be seen in the brain.

Forebrain medical issues;

Disturbances in the balance (number and species diversity) of the intestinal microbiota content and restoration of balance

Increase in intestinal permeability

Increase in blood-brain-barrier permeability

Intestinal inflammation

Insufficiency of ATP synthesis, which is the bio-energy source from mitochondria, which are the energy factories of our body, which negatively affects many systems.

DNA methylation disorders

Amino acid balance and disorders

General metabolic balance and disorders

Epigenetic changes

Sufficient and balanced synthesis of neurotransmitters, which are the mediator molecules of signal transmission in the nerves, and many systems should be examined from a medical perspective and necessary repairs should be made.

In the brain;

Inflammation that also affects nerve cells

Oxidative stress activation resulting in the release of free radicals and reactive oxygen intermediates

Increase in the number and dysfunction of intracerebral immune cells

Synaptic pruning dysfunctions of nerve cells

Disorders that can be seen in signal transmission systems in nerve cells etc.

Providing medical repair of many pathological changes

Pre-brain factors can contribute to triggering and sustaining intracerebral changes.